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HRID1766517

反应详情

EQUATION

反应方程式

HRID 1766517 的结构方程式

REACTANTS

反应物

4
结构：OB(O)c1ccc(Cl)cc1
HCID74299

Benzeneboronic acid, p-chloro-

C6H6BClO2

结构：O=C(O)c1cnc(Cl)c(Br)c1
HCID285433

5-bromo-6-chloronicotinic acid

C6H3BrClNO2

结构：N[C@@H]1CCCC[C@H]1O
HCID735777

(1R,2R)-2-Aminocyclohexanol

C6H13NO

结构：Cc1cc(CO)on1
HCID10820493

(3-methylisoxazol-5-yl)methanol

C5H7NO2

PRODUCTS

生成物

1
结构：Cc1cc(COc2ncc(C(=O)N[C@@H]3CCCC[C@H]3O)cc2-c2ccc(Cl)cc2)on1
HCID11950060

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, 3-methyl-5-isoxazolemethanol, (4-chloro-phenyl)-boronic acid and (1R,2R)-2-amino-cyclohexanol as starting materials to yield 5-(4-chloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(3-methyl-isoxazol-5-ylmethoxy)-nicotinamide, MS (ISP) 442.4, 444.4 (M+H)+.

WORKUP

后处理

  1. customThe title compound was synthesized in analogy to Example 75