HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenylboronic acid → racemic 5-(4-chloro-phenyl)-N-(2-hydroxymethyl-butyl)-6-(3-methyl-isoxazol-5-ylmethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Reactant | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| Reactant | (3-Methylisoxazol-5-yl)methanol | HCID 10820493 | — |
| Reactant | 2-(Aminomethyl)butan-1-ol | HCID 15356533 | — |
| Product | racemic 5-(4-chloro-phenyl)-N-(2-hydroxymethyl-butyl)-6-(3-methyl-isoxazol-5-ylmethoxy)-nicotinamide | HCID 11950062 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, 3-methyl-5-isoxazolemethanol, (4-chloro-phenyl)-boronic acid and 2-aminomethyl-1-butanol as starting materials to yield racemic 5-(4-chloro-phenyl)-N-(2-hydroxymethyl-butyl)-6-(3-methyl-isoxazol-5-ylmethoxy)-nicotinamide, MS (ISP) 430.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07229999B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-9869a01739cf4fe696eb1f5f8b53910e |
| Source note | uspto-grants-2007_06 |