反应详情

The two title compounds were synthesized in analogy to the procedure described for the preparation of Example 23, using 5-bromo-6-chloro-nicotinic acid methyl ester, cyclopropylmethanol (commercially available), 4-trifluoromethylphenylboronic acid (commercially available) and 2-cyclopropyl-2-hydroxy-propylamine (commercially available) as starting materials and separated into the two enantiomers by column chromatography on chiral phase.

1. customThe two title compounds were synthesized in analogy to the procedure
2. customdescribed for the preparation of Example 23
3. customseparated into the two enantiomers by column chromatography on chiral phase