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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1766521Generated: October 28, 2026

Cyclopropanemethanol → HCID 11950066, compound

https://huagongshe.com/reaction/1766521

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclopropanemethanolHCID 75644—
Reactant5-Bromo-6-chloropyridine-3-carboxylic acidHCID 285433—
Reactant4-(Trifluoromethoxy)phenylboronic acidHCID 2734386—
Reactant1-Amino-2-cyclopropylpropan-2-olHCID 21109692—
ProductHCID 11950066HCID 11950066—

Reaction Steps

The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-(trifluoromethoxy)-phenylboronic acid and 1-amino-2-cyclopropyl-propan-2-ol as starting materials to yield (RS)-N-(2-cyclopropyl-2-hydroxy-propyl)-6-cyclopropylmethoxy-5-(4-trifluoro-methoxy-phenyl)-nicotinamide. MS (ISP) 451.3 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07229999B2
Source datasetuspto-grants-2007_06
ORD IDord-c2c1590175cb478890eb96889d8649e0
Source noteuspto-grants-2007_06