反应详情

The title compound was synthesized in analogy to the procedure described for the preparation of Example 23, using 5-bromo-6-chloro-nicotinic acid methyl ester, cyclopropylmethanol (commercially available), 4-fluorophenylboronic acid (commercially available) and 2-cyclopropyl-2-hydroxy-propylamine (commercially available) as starting materials. The two enantiomers were separated by column chromatography on chiral phase. MS (m/e): 385.3 (MH+).

1. customdescribed for the preparation of Example 23
2. customThe two enantiomers were separated by column chromatography on chiral phase