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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1766550Generated: November 1, 2026

Cyclopropanemethanol → (RS)-6-cyclopropylmethoxy-N-(2-hydroxymethyl-butyl)-5-(4-trifluoromethoxy-phenyl)-nicotinamide

https://huagongshe.com/reaction/1766550

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclopropanemethanolHCID 75644—
Reactant5-Bromo-6-chloropyridine-3-carboxylic acidHCID 285433—
Reactant4-(Trifluoromethoxy)phenylboronic acidHCID 2734386—
Reactant2-(Aminomethyl)butan-1-olHCID 15356533—
Product(RS)-6-cyclopropylmethoxy-N-(2-hydroxymethyl-butyl)-5-(4-trifluoromethoxy-phenyl)-nicotinamideHCID 21109660—

Reaction Steps

The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-trifluoromethoxy-phenylboronic acid and 2-(aminomethyl)-1-butanol as starting materials to yield (RS)-6-cyclopropylmethoxy-N-(2-hydroxymethyl-butyl)-5-(4-trifluoromethoxy-phenyl)-nicotinamide. M0S (ISP) 439.0 (M+H)+

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07229999B2
Source datasetuspto-grants-2007_06
ORD IDord-38653328656847a78576ba2d71892fb2
Source noteuspto-grants-2007_06