HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanol → (RS)-6-cyclopropylmethoxy-N-(2-hydroxymethyl-butyl)-5-(4-trifluoromethyl-phenyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanol | HCID 75644 | — |
| Reactant | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Reactant | 2-(Aminomethyl)butan-1-ol | HCID 15356533 | — |
| Product | (RS)-6-cyclopropylmethoxy-N-(2-hydroxymethyl-butyl)-5-(4-trifluoromethyl-phenyl)-nicotinamide | HCID 21109661 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-trifluoromethyl-phenylboronic acid and 2-(aminomethyl)-1-butanol as starting materials to yield (RS)-6-cyclopropylmethoxy-N-(2-hydroxymethyl-butyl)-5-(4-trifluoromethyl-phenyl)-nicotinamide. MS (ISP) 423.3 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07229999B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-394141f112c748f7a2bf6073bb70c6a7 |
| Source note | uspto-grants-2007_06 |