HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanol → HCID 21109633, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanol | HCID 75644 | — |
| Reactant | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| Reactant | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| Reactant | 1-Amino-2-cyclopropylpropan-2-ol | HCID 21109692 | — |
| Product | HCID 21109633 | HCID 21109633 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-cyanophenylboronic acid and (+)-1-amino-2-cyclopropyl-propan-2-ol as starting materials to yield (+)-5-(4-cyano-phenyl)-N-(2-cyclopropyl-2-hydroxy-propyl)-6-cyclopropylmethoxy-nicotinamide. MS (ISP) 392.2 (M+H)+, αD20: +1.7° in MeOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07229999B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-ac339244d54b449c9dc1dd07b05bb9ff |
| Source note | uspto-grants-2007_06 |