HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenylboronic acid → HCID 68812519, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Reactant | Methyl 5-bromo-6-chloronicotinate | HCID 2764313 | — |
| Reactant | Methyl((4-methyl-1,3-thiazol-2-yl)methyl)amine | HCID 3928654 | — |
| Reactant | Cyclohexanol, 2-amino-, hydrochloride (1:1), (1R,2R)- | HCID 12228412 | — |
| Product | HCID 68812519 | HCID 68812519 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 74, using 5-bromo-6-chloro-nicotinic acid methyl ester, methyl-(4-methyl-thiazol-2-ylmethyl)-amine (CAS [644950-37-8]), (4-chloro-phenyl)-boronic acid and (1R,2R)-2-amino-cyclohexanol hydrochloride as starting materials to yield 5-(4-chloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-[methyl-(4-methyl-thiazol-2-ylmethyl)-amino]-nicotinamide. MS (ISP) 471.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07229999B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-336a865b4499491f9e4fcb215ebec4d0 |
| Source note | uspto-grants-2007_06 |