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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1766564Generated: October 31, 2026

5-Bromo-6-chloropyridine-3-carboxylic acid → HCID 68812630, compound

https://huagongshe.com/reaction/1766564

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromo-6-chloropyridine-3-carboxylic acidHCID 285433—
Reactant4-Fluorophenylboronic acidHCID 285645—
Reactant(1R,2R)-2-AminocyclohexanolHCID 735777—
Reactant(5-Methyl-1,2-oxazol-3-yl)methanolHCID 2736567—
ProductHCID 68812630HCID 68812630—

Reaction Steps

The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, 5-methyl-3-isoxazolemethanol, (4-fluoro-phenyl)-boronic acid and ((1R,2R)-2-amino-1-cyclohexanol as starting materials to yield 5-(4-fluoro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(5-methyl-isoxazol-3-ylmethoxy)-nicotinamide, MS (ISP) 426.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07229999B2
Source datasetuspto-grants-2007_06
ORD IDord-6842ace272ee45df8cde773815df1212
Source noteuspto-grants-2007_06