HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-6-chloropyridine-3-carboxylic acid → HCID 68811772, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | (5-Methyl-1,2-oxazol-3-yl)methanol | HCID 2736567 | — |
| Reactant | (2R)-1-amino-2-cyclopropyl-propan-2-ol | HCID 51684102 | — |
| Product | HCID 68811772 | HCID 68811772 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, 5-methyl-3-isoxazolemethanol, (4-fluoro-phenyl)-boronic acid and (R)-α-(aminomethyl)-α-methyl-cyclopropanemethanol as starting materials to yield N-((R)-2-cyclopropyl-2-hydroxy-propyl)-5-(4-fluoro-phenyl)-6-(5-methyl-isoxazol-3-ylmethoxy)-nicotinamide, MS (ISP) 426.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07229999B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-df30b4d2ec0a46edad859296e3308279 |
| Source note | uspto-grants-2007_06 |