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HRID1766569

反应详情

EQUATION

反应方程式

HRID 1766569 的结构方程式

REACTANTS

反应物

4
结构：OCC1CC1
HCID75644

Cyclopropylmethanol

C4H8O

结构：O=C(O)c1cnc(Cl)c(Br)c1
HCID285433

5-bromo-6-chloronicotinic acid

C6H3BrClNO2

结构：OB(O)c1ccc(C(F)(F)F)cc1
HCID2734389

4-(Trifluoromethyl)phenylboronic acid

C7H6BF3O2

结构：CC(O)(CN)C(F)(F)F
HCID13620759

3-Amino-1,1,1-trifluoro-2-methylpropan-2-ol

C4H8F3NO

PRODUCTS

生成物

1
结构：CC(O)(CNC(=O)c1cnc(OCC2CC2)c(-c2ccc(C(F)(F)F)cc2)c1)C(F)(F)F
HCID21109688

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-trifluoromethyl-phenylboronic acid and 3-amino-1,1,1-trifluoro-2-methyl-propan-2-ol (CAS [354-68-7]) as starting materials to yield (RS)-6-cyclopropylmethoxy-N-(3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-5-(4-trifluoromethyl-phenyl)-nicotinamide. MS (ISP) 463.0 (M+H)+.

WORKUP

后处理

  1. customThe title compound was synthesized in analogy to Example 75