huagongshe.com
HRID1766579

反应详情

EQUATION

反应方程式

HRID 1766579 的结构方程式

REACTANTS

反应物

4
结构：OCc1ccncc1
HCID11472

4-Pyridinemethanol

C6H7NO

结构：O=C(O)c1cnc(Cl)c(Br)c1
HCID285433

5-bromo-6-chloronicotinic acid

C6H3BrClNO2

结构：N[C@@H]1CCCC[C@H]1O
HCID735777

(1R,2R)-2-Aminocyclohexanol

C6H13NO

结构：N#Cc1ccc(B(O)O)cc1
HCID2734326

4-Cyanophenylboronic acid

C7H6BNO2

PRODUCTS

生成物

1
结构：N#Cc1ccc(-c2cc(C(=O)N[C@@H]3CCCC[C@H]3O)cnc2OCC2CC2)cc1
HCID24856637

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, 4-pyridinemethanol, (4-cyano-phenyl)-boronic acid and ((1R,2R)-2-amino-1-cyclohexanol as starting materials to yield 5-(4-cyano-phenyl)-6-cyclopropylmethoxy-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide, MS (ISP) 392.2 (M+H)+.

WORKUP

后处理

  1. customThe title compound was synthesized in analogy to Example 75