Hydrochloric Acid → HCID 9825159, compound

Participants

Reaction Steps

Sodium hydroxide solution (0.3 ml of 2M, 0.6 mmol) was added to a stirred suspension of 2-(2-chlorobenzyloxy)-4-[N-(5-ethoxycarbonylthiazol-2-yl)carbamoyl]-6-methylquinoline (Method 1; 0.097 g, 0.202 mmol) in THF (5 ml) and water (2 ml), and the reaction mixture stirred at ambient temperature for 4 hrs. The reaction mixture was adjusted to pH 4–5 with aqueous hydrochloric acid (1M), and concentrated in vacuo. The solid thus precipitated was filtered, washed with water and dried to give the title compound as a colourless solid (0.030 g, 33%). NMR: 2.45 (3H, s), 5.60 (2H, s), 7.40 (3H, m), 7.50 (1H, m), 7.60 (1H, d), 7.65 (1H, m), 7.80 (2H, t), 7.90 (1H, d), 8.15 (1H, s); m/z

Provenance & Evidence