Hydrochloric Acid → HCID 21111658, compound

Participants

Reaction Steps

To 2-(2-chlorobenzyloxy)-4-(2-chlorobenzyloxycarbonyl)-6-methylquinoline (Method 11; 0.980 g, 2.173 mmol) in THF (100 ml) was added a solution of sodium hydroxide (261 mg, 6.519 mmol) in water (2.6 ml) followed by water (60 ml) and methanol (10 ml). The reaction mixture was stirred at ambient temperature for 2 hrs 30 min and then adjusted to pH 4–5 with 1M HCl. It was then concentrated in vacuo and the resulting solid filtered, washed with water, and dried to give the title compound as a colourless solid (0.704 g, 99%). NMR: 2.45 (3H, s), 5.60 (2H, s), 7.35 (3H, m), 7.50 (1H, m), 7.55 (1H, dd), 7.65 (1H, m), 7.75 (1H, d), 8.30 (1H, s); m/z 328 (M+H)+, 326 (M−H)−.

Provenance & Evidence