HCID 11315175, compound → HCID 86600875, compound

HRID 1766608Notes

Reaction equation

[CH2:1]([C:3]1[N:11]=[C:10]([O:12][CH3:13])[C:9]([NH:14][C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[C:25]([O:31][CH3:32])[CH:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:8][C:4]=1[C:5](O)=[O:6])[CH3:2].[CH:33]1[C:46]2[C:37](=[N:38][C:39]3[C:44]([C:45]=2[NH:47][C:48]2[CH:49]=[C:50]([NH:56][C:57](=[O:61])[CH:58]([NH2:60])[CH3:59])[CH:51]=[C:52]([CH2:54][OH:55])[CH:53]=2)=[CH:43][CH:42]=[CH:41][CH:40]=3)[CH:36]=[CH:35][CH:34]=1>>[CH:43]1[C:44]2[C:39](=[N:38][C:37]3[C:46]([C:45]=2[NH:47][C:48]2[CH:49]=[C:50]([NH:56][C:57]([CH:58]([NH:60][C:5]([C:4]4[CH:8]=[C:9]([NH:14][C:15]([N:17]5[CH2:18][CH2:19][N:20]([C:23]6[CH:24]=[C:25]([O:31][CH3:32])[CH:26]=[C:27]([O:29][CH3:30])[CH:28]=6)[CH2:21][CH2:22]5)=[O:16])[C:10]([O:12][CH3:13])=[N:11][C:3]=4[CH2:1][CH3:2])=[O:6])[CH3:59])=[O:61])[CH:51]=[C:52]([CH2:54][OH:55])[CH:53]=2)=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:40]=[CH:41][CH:42]=1

Participants

Reactant 2

HCID 11315175HCID 11315175, compound

HCID 21111624HCID 21111624, compound

Product 1

HCID 86600875HCID 86600875, compoundYield 49.1%

Procedure

The same reaction procedure to the example 1 were carried out using 2-ethyl-5-{[4-(3,5-dimethoxyphenyl)-piperazine-1-carbonyl]-amino}-6-meth oxy-nicotinic acid and N-[3-(acridine-9-yl-amino)-5-hydroxymethyl-phenyl]-2-aminopropaneamide to give the titled compound.

Workup

customThe same reaction procedure to the example 1

Sources & evidence

ORD record: ord-281ed5378896453a8949127ca78eb368
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07230105B2

Reaction notes

Loading…