HCID 11315175, compound → HCID 86600879, compound

HRID 1766612Notes

Reaction equation

HRID 1766612 reaction equation
[CH2:1]([C:3]1[N:11]=[C:10]([O:12][CH3:13])[C:9]([NH:14][C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([OH:29])[CH:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:8][C:4]=1[C:5]([OH:7])=O)[CH3:2].[CH:30]1[C:43]2[C:34](=[N:35][C:36]3[C:41]([C:42]=2[NH:44][C:45]2[CH:46]=[C:47]([NH:53][C:54](=[O:58])[CH:55]([NH2:57])[CH3:56])[CH:48]=[C:49]([CH2:51][OH:52])[CH:50]=2)=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH:33]=[CH:32][CH:31]=1>>[CH:40]1[C:41]2[C:36](=[N:35][C:34]3[C:43]([C:42]=2[NH:44][C:45]2[CH:46]=[C:47]([NH:53][C:54]([CH:55]([NH:57][C:5]([C:4]4[CH:8]=[C:9]([NH:14][C:15]([N:17]5[CH2:22][CH2:21][N:20]([C:23]6[CH:28]=[CH:27][CH:26]=[C:25]([OH:29])[CH:24]=6)[CH2:19][CH2:18]5)=[O:16])[C:10]([O:12][CH3:13])=[N:11][C:3]=4[CH2:1][CH3:2])=[O:7])[CH3:56])=[O:58])[CH:48]=[C:49]([CH2:51][OH:52])[CH:50]=2)=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:37]=[CH:38][CH:39]=1

Participants

3

Reactant 2

HCID 11315175HCID 11315175, compoundHCID 21111626HCID 21111626, compound

Product 1

HCID 86600879HCID 86600879, compoundYield 41.9%

Procedure

The same reaction procedure to the example 1 were carried out using 2-ethyl-5-{[4-(3-hydroxyphenyl)-piperazine-1-carbonyl]-amino}-6-methoxy-nicotinic acid and N-[3-(acridine-9-yl-amino)-5-hydroxymethyl-phenyl]-2-aminopropaneamide to give the titled compound.

Workup

  1. customThe same reaction procedure to the example 1

Sources & evidence

ORD record
ord-93f5c3613f33490c8029d1cbebcecfe8
Source dataset
uspto-grants-2007_06
Patent number
US07230105B2

Reaction notes

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