HCID 11315175, compound → HCID 86600880, compound

HRID 1766613Notes

Reaction equation

[CH2:1]([C:3]1[N:11]=[C:10]([O:12][CH3:13])[C:9]([NH:14][C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[C:27]([O:29][CH3:30])[C:26]([O:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:8][C:4]=1[C:5](O)=[O:6])[CH3:2].[CH:35]1[C:48]2[C:39](=[N:40][C:41]3[C:46]([C:47]=2[NH:49][C:50]2[CH:51]=[C:52]([NH:58][C:59](=[O:63])[CH:60]([NH2:62])[CH3:61])[CH:53]=[C:54]([CH2:56][OH:57])[CH:55]=2)=[CH:45][CH:44]=[CH:43][CH:42]=3)[CH:38]=[CH:37][CH:36]=1>>[CH:45]1[C:46]2[C:41](=[N:40][C:39]3[C:48]([C:47]=2[NH:49][C:50]2[CH:51]=[C:52]([NH:58][C:59]([CH:60]([NH:62][C:5]([C:4]4[CH:8]=[C:9]([NH:14][C:15]([N:17]5[CH2:22][CH2:21][N:20]([C:23]6[CH:24]=[C:25]([O:33][CH3:34])[C:26]([O:31][CH3:32])=[C:27]([O:29][CH3:30])[CH:28]=6)[CH2:19][CH2:18]5)=[O:16])[C:10]([O:12][CH3:13])=[N:11][C:3]=4[CH2:1][CH3:2])=[O:6])[CH3:61])=[O:63])[CH:53]=[C:54]([CH2:56][OH:57])[CH:55]=2)=[CH:35][CH:36]=[CH:37][CH:38]=3)[CH:42]=[CH:43][CH:44]=1

Participants

Reactant 2

HCID 11315175HCID 11315175, compound

HCID 21111621HCID 21111621, compound

Product 1

HCID 86600880HCID 86600880, compoundYield 44.3%

Procedure

The same reaction procedure to the example 1 were carried out using 2-ethyl-5-{[4-(3,4,5-trimethoxyphenyl)-piperazine-1-carbonyl]-amino}-6-methoxy-nicotinic acid and N-[3-(acridine-9-yl-amino)-5-hydroxymethyl-phenyl]-2-aminopropaneamide to give the titled compound.

Workup

customThe same reaction procedure to the example 1

Sources & evidence

ORD record: ord-36d8d7e2bdaa466aaed971e785cd90c7
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07230105B2

Reaction notes

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