HCID 11315175, compound → HCID 86600881, compound

HRID 1766614Notes

Reaction equation

HRID 1766614 reaction equation
[CH2:1]([C:4]1[N:12]=[C:11]([O:13][CH3:14])[C:10]([NH:15][C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[CH:29]=[C:28]([O:30][CH3:31])[CH:27]=[C:26]([O:32][CH3:33])[CH:25]=3)[CH2:20][CH2:19]2)=[O:17])=[CH:9][C:5]=1[C:6](O)=[O:7])[CH2:2][CH3:3].[CH:34]1[C:47]2[C:38](=[N:39][C:40]3[C:45]([C:46]=2[NH:48][C:49]2[CH:50]=[C:51]([NH:57][C:58](=[O:62])[CH:59]([NH2:61])[CH3:60])[CH:52]=[C:53]([CH2:55][OH:56])[CH:54]=2)=[CH:44][CH:43]=[CH:42][CH:41]=3)[CH:37]=[CH:36][CH:35]=1>>[CH:44]1[C:45]2[C:40](=[N:39][C:38]3[C:47]([C:46]=2[NH:48][C:49]2[CH:50]=[C:51]([NH:57][C:58]([CH:59]([NH:61][C:6]([C:5]4[CH:9]=[C:10]([NH:15][C:16]([N:18]5[CH2:19][CH2:20][N:21]([C:24]6[CH:25]=[C:26]([O:32][CH3:33])[CH:27]=[C:28]([O:30][CH3:31])[CH:29]=6)[CH2:22][CH2:23]5)=[O:17])[C:11]([O:13][CH3:14])=[N:12][C:4]=4[CH2:1][CH2:2][CH3:3])=[O:7])[CH3:60])=[O:62])[CH:52]=[C:53]([CH2:55][OH:56])[CH:54]=2)=[CH:34][CH:35]=[CH:36][CH:37]=3)[CH:41]=[CH:42][CH:43]=1

Participants

3

Reactant 2

HCID 11315175HCID 11315175, compoundHCID 21111628HCID 21111628, compound

Product 1

HCID 86600881HCID 86600881, compoundYield 41.2%

Procedure

The same reaction procedure to the example 1 were carried out using 2-propyl-5-{[4-(3,5-dimethoxyphenyl)-piperazine-1-carbonyl]-amino}-6-methoxy-nicotinic acid and N-[3-(acridine-9-yl-amino)-5-hydroxymethyl-phenyl]-2-aminopropaneamide to give the titled compound.

Workup

  1. customThe same reaction procedure to the example 1

Sources & evidence

ORD record
ord-2808491afa08420dbdc19ffe169e5043
Source dataset
uspto-grants-2007_06
Patent number
US07230105B2

Reaction notes

Loading…