HCID 11315175, compound → HCID 86600882, compound

HRID 1766615Notes

Reaction equation

HRID 1766615 reaction equation
[CH2:1]([C:4]1[N:12]=[C:11]([O:13][CH3:14])[C:10]([NH:15][C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[CH:29]=[C:28]([CH3:30])[CH:27]=[C:26]([CH3:31])[CH:25]=3)[CH2:20][CH2:19]2)=[O:17])=[CH:9][C:5]=1[C:6](O)=[O:7])[CH2:2][CH3:3].[CH:32]1[C:45]2[C:36](=[N:37][C:38]3[C:43]([C:44]=2[NH:46][C:47]2[CH:48]=[C:49]([NH:55][C:56](=[O:60])[CH:57]([NH2:59])[CH3:58])[CH:50]=[C:51]([CH2:53][OH:54])[CH:52]=2)=[CH:42][CH:41]=[CH:40][CH:39]=3)[CH:35]=[CH:34][CH:33]=1>>[CH:42]1[C:43]2[C:38](=[N:37][C:36]3[C:45]([C:44]=2[NH:46][C:47]2[CH:48]=[C:49]([NH:55][C:56]([CH:57]([NH:59][C:6]([C:5]4[CH:9]=[C:10]([NH:15][C:16]([N:18]5[CH2:23][CH2:22][N:21]([C:24]6[CH:25]=[C:26]([CH3:31])[CH:27]=[C:28]([CH3:30])[CH:29]=6)[CH2:20][CH2:19]5)=[O:17])[C:11]([O:13][CH3:14])=[N:12][C:4]=4[CH2:1][CH2:2][CH3:3])=[O:7])[CH3:58])=[O:60])[CH:50]=[C:51]([CH2:53][OH:54])[CH:52]=2)=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:39]=[CH:40][CH:41]=1

Participants

3

Reactant 2

HCID 11315175HCID 11315175, compoundHCID 21111629HCID 21111629, compound

Product 1

HCID 86600882HCID 86600882, compoundYield 42.3%

Procedure

The same reaction procedure to the example 1 were carried out using 2-propyl-5-{[4-(3,5-dimethylphenyl)-piperazine-1-carbonyl]-amino}-6-methoxy-nicotinic acid and N-[3-(acridine-9-yl-amino)-5-hydroxymethyl-phenyl]-2-aminopropaneamide to give the titled compound.

Workup

  1. customThe same reaction procedure to the example 1

Sources & evidence

ORD record
ord-c845247ef35841ce8ec3991154b80ff3
Source dataset
uspto-grants-2007_06
Patent number
US07230105B2

Reaction notes

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