3-(9-Acridinylamino)-5-hydroxymethylaniline → HCID 21111636, compound

HRID 1766618Notes

Reaction equation

HRID 1766618 reaction equation
[CH2:1]([C:3]1[N:11]=[C:10]([O:12][CH3:13])[C:9]([NH:14][C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[C:25]([O:31][CH3:32])[CH:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:8][C:4]=1[C:5](O)=[O:6])[CH3:2].[CH:33]1[C:46]2[C:37](=[N:38][C:39]3[C:44]([C:45]=2[NH:47][C:48]2[CH:49]=[C:50]([CH2:55][OH:56])[CH:51]=[C:52]([NH2:54])[CH:53]=2)=[CH:43][CH:42]=[CH:41][CH:40]=3)[CH:36]=[CH:35][CH:34]=1>>[CH:33]1[C:46]2[C:37](=[N:38][C:39]3[C:44]([C:45]=2[NH:47][C:48]2[CH:53]=[C:52]([NH:54][C:5]([C:4]4[CH:8]=[C:9]([NH:14][C:15]([N:17]5[CH2:18][CH2:19][N:20]([C:23]6[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[C:25]([O:31][CH3:32])[CH:24]=6)[CH2:21][CH2:22]5)=[O:16])[C:10]([O:12][CH3:13])=[N:11][C:3]=4[CH2:1][CH3:2])=[O:6])[CH:51]=[C:50]([CH2:55][OH:56])[CH:49]=2)=[CH:43][CH:42]=[CH:41][CH:40]=3)[CH:36]=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 3804823-(9-Acridinylamino)-5-hydroxymethylanilineHCID 21111624HCID 21111624, compound

Product 1

HCID 21111636HCID 21111636, compoundYield 70.2%

Procedure

The same reaction procedure to the example 18 were carried out using 2-ethyl-5-{[4-(3,5-dimethoxyphenyl)-piperazine-1-carbonyl]-amino}-6-methoxynicotinic acid and [3-(acridine-9-yl-amino)-5-aminophenyl]-methanol to give the titled compound.

Workup

  1. customThe same reaction procedure to the example 18

Sources & evidence

ORD record
ord-a887dbfba1354a288e5cfff37f9f9ca0
Source dataset
uspto-grants-2007_06
Patent number
US07230105B2

Reaction notes

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