3-(9-Acridinylamino)-5-hydroxymethylaniline → HCID 21111640, compound

HRID 1766621Notes

Reaction equation

HRID 1766621 reaction equation
[CH2:1]([C:3]1[N:11]=[C:10]([O:12][CH3:13])[C:9]([NH:14][C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:8][C:4]=1[C:5]([OH:7])=O)[CH3:2].[CH:30]1[C:43]2[C:34](=[N:35][C:36]3[C:41]([C:42]=2[NH:44][C:45]2[CH:46]=[C:47]([CH2:52][OH:53])[CH:48]=[C:49]([NH2:51])[CH:50]=2)=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH:33]=[CH:32][CH:31]=1>>[CH:30]1[C:43]2[C:34](=[N:35][C:36]3[C:41]([C:42]=2[NH:44][C:45]2[CH:50]=[C:49]([NH:51][C:5]([C:4]4[CH:8]=[C:9]([NH:14][C:15]([N:17]5[CH2:18][CH2:19][N:20]([C:23]6[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=6)[CH2:21][CH2:22]5)=[O:16])[C:10]([O:12][CH3:13])=[N:11][C:3]=4[CH2:1][CH3:2])=[O:7])[CH:48]=[C:47]([CH2:52][OH:53])[CH:46]=2)=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH:33]=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 3804823-(9-Acridinylamino)-5-hydroxymethylanilineHCID 21111625HCID 21111625, compound

Product 1

HCID 21111640HCID 21111640, compoundYield 72.1%

Procedure

The same reaction procedure to the example 18 were carried out using 2-ethyl-5-{[4-(3-fluorophenyl)-piperazine-1-carbonyl]-amino}-6-methoxynicotinic acid and [3-(acridine-9-yl-amino)-5-aminophenyl]-methanol to give the titled compound.

Workup

  1. customThe same reaction procedure to the example 18

Sources & evidence

ORD record
ord-f57d21ae70e0430bbaf52b068aedfa2c
Source dataset
uspto-grants-2007_06
Patent number
US07230105B2

Reaction notes

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