3-(9-Acridinylamino)-5-hydroxymethylaniline → HCID 21111631, compound

HRID 1766622Notes

Reaction equation

HRID 1766622 reaction equation
[CH2:1]([C:3]1[N:11]=[C:10]([O:12][CH3:13])[C:9]([NH:14][C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[C:27]([O:29][CH3:30])[C:26]([O:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:8][C:4]=1[C:5](O)=[O:6])[CH3:2].[CH:35]1[C:48]2[C:39](=[N:40][C:41]3[C:46]([C:47]=2[NH:49][C:50]2[CH:51]=[C:52]([CH2:57][OH:58])[CH:53]=[C:54]([NH2:56])[CH:55]=2)=[CH:45][CH:44]=[CH:43][CH:42]=3)[CH:38]=[CH:37][CH:36]=1>>[CH:35]1[C:48]2[C:39](=[N:40][C:41]3[C:46]([C:47]=2[NH:49][C:50]2[CH:55]=[C:54]([NH:56][C:5]([C:4]4[CH:8]=[C:9]([NH:14][C:15]([N:17]5[CH2:18][CH2:19][N:20]([C:23]6[CH:24]=[C:25]([O:33][CH3:34])[C:26]([O:31][CH3:32])=[C:27]([O:29][CH3:30])[CH:28]=6)[CH2:21][CH2:22]5)=[O:16])[C:10]([O:12][CH3:13])=[N:11][C:3]=4[CH2:1][CH3:2])=[O:6])[CH:53]=[C:52]([CH2:57][OH:58])[CH:51]=2)=[CH:45][CH:44]=[CH:43][CH:42]=3)[CH:38]=[CH:37][CH:36]=1

Participants

3

Reactant 2

HCID 3804823-(9-Acridinylamino)-5-hydroxymethylanilineHCID 21111621HCID 21111621, compound

Product 1

HCID 21111631HCID 21111631, compoundYield 66.8%

Procedure

The same reaction procedure to the example 18 were carried out using 2-ethyl-5-{[4-(3,4,5-trimethoxyphenyl)-piperazine-1-carbonyl]-amino}-6-methoxynicotinic acid and [3-(acridine-9-yl-amino)-5-aminophenyl]-methanol to give the titled compound.

Workup

  1. customThe same reaction procedure to the example 18

Sources & evidence

ORD record
ord-b6134220f67f497abcc5f2fae4eccf5b
Source dataset
uspto-grants-2007_06
Patent number
US07230105B2

Reaction notes

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