反应详情

温度

50 °C

A solution of pyridinium tribromide 90% (8.72 g, 24.5 mmol) in acetic acid 50% (50 mL) was added to a solution of 4-[2-(dipropylamino)ethyl]indol (IV) (5 g, 20.5 mmol) in acetic acid 50% (100 mL) and was stirred at 50° C. for 3 h. When the resultant mixture reached room temperature, it was stirred at this temperature for 16 h. The reaction mixture was concentrated to obtain an aqueous residue, which was diluted with water (100 mL), basified with an aqueous solution of NaOH 10% and extracted with AcOEt. The organic layer was dried, filtered and concentrated to obtain 4.3 g (81%) of 4-[2-(dipropylamino)ethyl]indol-2-one (I).

1. customreached room temperature
2. stirringit was stirred at this temperature for 16 h
3. concentrationThe reaction mixture was concentrated
4. customto obtain an aqueous residue, which
5. extractionextracted with AcOEt
6. customThe organic layer was dried
7. filtrationfiltered
8. concentrationconcentrated