反应详情

[2-benzyloxy-5-(5-methyl-7-nitroindan-4-yloxy)phenyl]methanol (2.48 g) was dissolved in diethyl ether. After adding dropwise thionyl chloride (5 mL) under ice-cooling with stirring, the mixture was stirred at room temperature for 6 hours. The reaction mixture was evaporated under reduced pressure to dryness. After adding water (10 mL), the residue was extracted with diethyl ether. The organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (2.04 g).

1. temperaturecooling
2. stirringthe mixture was stirred at room temperature for 6 hours
3. customThe reaction mixture was evaporated under reduced pressure to dryness
4. additionAfter adding water (10 mL)
5. extractionthe residue was extracted with diethyl ether
6. washThe organic layer was washed with brine
7. dry with materialdried over anhydrous magnesium sulfate
8. customThe solvent was removed under reduced pressure