反应详情

A suspension of 3-chloro-6-[2-methoxy-5-(5-methyl-7-nitroindan-4-yloxy)benzyl]pyridazine (760 mg) and sodium acetate (50 mg)in acetic acid (10 mL) was heated at reflux temperature under an argon atmosphere for 2 hours. The reaction mixture was evaporated under reduced pressure to dryness. After adding water (15 mL), the residue was stirred for 30 min. The mixture was extracted with dichloromethane. The organic layer was washed with a saturated aqueous of sodium hydrogen carbonate and brine successively, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give 6-[2-methoxy-5-(5-methyl-7-nitroindan-4-yloxy)benzyl]-2H-pyridazine-3-one (707 mg).

1. temperaturewas heated
2. temperatureat reflux temperature under an argon atmosphere for 2 hours
3. customThe reaction mixture was evaporated under reduced pressure to dryness
4. additionAfter adding water (15 mL)
5. extractionThe mixture was extracted with dichloromethane
6. washThe organic layer was washed with a saturated aqueous of sodium hydrogen carbonate and brine successively
7. dry with materialdried over anhydrous magnesium sulfate
8. customThe solvent was removed under reduced pressure