HCID 23031153, compound → HCID 23031220, compound

HRID 1766678Notes

Reaction equation

HRID 1766678 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([C:17]2[C:25]([CH3:26])=[CH:24][C:23]([N:27]([CH2:35][C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[C:22]3[C:18]=2[CH2:19][CH2:20][CH2:21]3)[OH:16])=[CH:11][C:10]=1[CH:42]([CH3:44])[CH3:43])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>ClCCl.[O-2].[Mn+4].[O-2]>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([C:17]2[C:25]([CH3:26])=[CH:24][C:23]([N:27]([CH2:35][C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=3)[CH2:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[C:22]3[C:18]=2[CH2:19][CH2:20][CH2:21]3)=[O:16])=[CH:11][C:10]=1[CH:42]([CH3:44])[CH3:43])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 23031153HCID 23031153, compound

Product 1

HCID 23031220HCID 23031220, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of (4-benzyloxy-3-isopropylphenyl)-(7-dibenzylamino-5-methylindan-4-yl)methanol (497 mg) in dichloromethane (10 mL) was added manganese (IV) oxide (2.98 g) at room temperature for 3 days. The insoluble material was removed by filtration. The filtrate was evaporated under reduced pressure to dryness to give the title compound (436 mg).

Workup

  1. customThe insoluble material was removed by filtration
  2. customThe filtrate was evaporated under reduced pressure to dryness

Sources & evidence

ORD record
ord-2a7f8a0d4e1f475aa22dd245561f16c9
Source dataset
uspto-grants-2007_06
Patent number
US07230031B2

Reaction notes

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