Acetic Acid → 1-[2-Methoxy-5-(5-methyl-7-nitroindan-4-yloxy)phenyl]ethanone

HRID 1766687Notes

Reaction equation

HRID 1766687 reaction equation
[CH3:1][O:2][C:3]1[CH:22]=[CH:21][C:6]([O:7][C:8]2[C:16]([CH3:17])=[CH:15][C:14]([N+:18]([O-:20])=[O:19])=[C:13]3[C:9]=2[CH2:10][CH2:11][CH2:12]3)=[CH:5][CH:4]=1.[C:23](O)(=[O:25])[CH3:24]>>[CH3:1][O:2][C:3]1[CH:22]=[CH:21][C:6]([O:7][C:8]2[C:16]([CH3:17])=[CH:15][C:14]([N+:18]([O-:20])=[O:19])=[C:13]3[C:9]=2[CH2:10][CH2:11][CH2:12]3)=[CH:5][C:4]=1[C:23](=[O:25])[CH3:24]

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 230311142,3-Dihydro-4-(4-methoxyphenoxy)-5-methyl-7-nitro-1H-indene

Product 1

HCID 211105591-[2-Methoxy-5-(5-methyl-7-nitroindan-4-yloxy)phenyl]ethanone

Procedure

The title compound was prepared in a similar manner to those described in Reference Example 56 using 4-(4-methoxyphenoxy)-5-methyl-7-nitroindane instead of ethyl N-[7-(4-methoxyphenoxy)-6-methylindan-4-yl]malonamate and using acetic acid instead of 4-fluorophenylacetic acid.

Sources & evidence

ORD record
ord-acd54e479e0f4f7d8e7b00fd403f8ce7
Source dataset
uspto-grants-2007_06
Patent number
US07230031B2

Reaction notes

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