HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Morpholin-4-ylethoxy)benzeneboronic acid, pinacol ester → 3-(2,6-Dichloro-benzyloxy)-5-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-pyridin-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Morpholin-4-ylethoxy)benzeneboronic acid, pinacol ester | HCID 4625910 | — |
| Reactant | 3-(2,6-Dichlorobenzyloxy)-5-bromopyridin-2-amine | HCID 21111487 | — |
| Product | 3-(2,6-Dichloro-benzyloxy)-5-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-pyridin-2-ylamine | HCID 10254297 | — |
Reaction Steps
3-(2,6-Dichloro-benzyloxy)-5-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-pyridin-2-ylamine was prepared from 5-bromo-3-(2,6-dichloro-benzyloxy)-pyridin-2-ylamine (example I(a)) and 4{2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-ethyl}-morpholine (prepared in part 1) following procedure 3 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07230098B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-a8ee18b7b5e64562b0ba74080d633130 |
| Source note | uspto-grants-2007_06 |