Hydrazine → HCID 58886642, compound

HRID 1766818Notes

Reaction equation

HRID 1766818 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:14]([C:15](O)=[O:16])=[CH:13][N:12]3[CH:18]=[CH:19][N:20]=[C:11]3[C:10]=2[Cl:21])=[C:4]([F:22])[CH:3]=1.COC(C1C(NC2C=CC(Br)=CC=2F)=C(Cl)C2N(C=CN=2)C=1)=O.[NH2:46][NH2:47]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:14]([C:15]([NH:46][NH2:47])=[O:16])=[CH:13][N:12]3[CH:18]=[CH:19][N:20]=[C:11]3[C:10]=2[Cl:21])=[C:4]([F:22])[CH:3]=1

Participants

5

Reactant 3

HCID 9321HydrazineHCID 21866995HCID 21866995, compoundHCID 58886646HCID 58886646, compound

Product 1

HCID 58886642HCID 58886642, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7-(4-Bromo-2-fluoro-phenylamino)-8-chloro-imidazo[1,2-a]pyridine-6-carboxylic acid was converted to the hydrazide according to the coupling conditions described in Step A of Example 3. Alternatively, the hydrazide can be prepared directly from 7-(4-Bromo-2-fluorophenylamino)-8-chloroimidazo[1,2-a]pyridine-6-carboxylic acid methyl ester by refluxing with hydrazine in ethanol. MS ESI (+) m/z 398, 400 (M+, Cl, Br pattern) detected.

Sources & evidence

ORD record
ord-eb23e5bbeb2e48c4b37434f4c14ec48c
Source dataset
uspto-grants-2007_06
Patent number
US07230099B2

Reaction notes

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