Trifluoroacetic acid → HCID 17862534, compound

Participants

Reaction Steps

According to a similar procedure to that described in Example 4-(6), 4-methoxybenzyl 2-[[bis(allyloxy)phosphoryl]oxymethyl]-5-cyanobenzoate (737 mg, 1.61 mmol) obtained from Example 5-(3), anisole (1.0 g, 9.2 mmol), and trifluoroacetic acid (5 ml) were reacted, and the reaction mixture was worked up to afford 2-[[bis(allyloxy)phosphoryl]oxymethyl]-5-cyanobenzoic acid as a crude product. According to a similar procedure to that described in Example 4-(6), the crude product obtained above, oxalyl chloride (1.27 g, 10 mmol), and N,N-dimethylformamide (15 μl) were reacted, and the reaction mixture was worked up to afford 2-[[bis(allyloxy)phosphoryl]oxymethyl]-5-cyanobenzoyl chloride as a crude product.

Provenance & Evidence