Trifluoroacetic acid → HCID 17862535, compound

Participants

Reaction Steps

According to a similar procedure to that described in Example 4-(6), 4-methoxybenzyl 2-[[bis(allyloxy)phosphoryl]oxymethyl]-4-fluorobenzoate (1.41 g, 3.12 mmol) obtained from Example 7-(1) was reacted with anisole (2 g, 18.5 mmol) and trifluoroacetic acid (5 ml), and the reaction mixture was worked up to afford 2-[[bis(allyloxy)phosphoryl]oxymethyl]-4-fluorobenzoic acid as a crude product. According to a similar procedure to that described in Example 4-(6), the crude product obtained above was reacted with oxalyl chloride (1.98 g, 15.6 mmol) and N,N-dimethylformamide (15 μl), and the reaction mixture was worked up to afford 2-[[bis(allyloxy)phosphoryl]oxymethyl]-4-fluorobenzoyl chloride as a crude product.

Provenance & Evidence