tert-Butyl hydroperoxide → HCID 178460586, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl]-1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-[(1H-1,2,4-triazol-1-yl)methyl]propyl(2-hydroxyethyl)carbonate (180 mg, 2.85×10−4 mol) obtained from Example 15 in dichloromethane (2 ml) were added tetrazole (40 mg, 5.7×10−4 mol) and bis(allyloxy)(diisopropylamino)phosphine (Tetrahedron Lett., 30, 4219 (1989); 105 mg, 4.28×10−4 mol) at room temperature, and the reaction mixture was stirred for 30 minutes. Allyl alcohol (0.1 ml) was added to the mixture at the same temperature, and the resulting mixture was stirred for 20 minutes further. The mixture was cooled to 0° C., and tert-butyl hydroperoxide (ca. 5M nonane solution; 1.5 ml, ca. 7.5 mmol) was added thereto, then the mixture was stirred at room temperature for 30 minutes. To the mixture were added a saturated aqueous solution of sodium hydrogen carbonate and an aqueous solution of sodium thiosulfate, then the resulting mixture was stirred for 10 minutes and partitioned between ethyl acetate and water. The organic layer was washed successively with a saturated aqueous solution of sodium hydrogen carbonate, a saturated aqueous solution of ammonium chloride, and an aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by recycle preparative HPLC [LC-908; Japan Analytical Industry Co., Ltd.; GPC column JAIGEL-LH (20 mm i.d.×600 mm) and JAIGEL-2H (20 mm i.d.×600 mm) connected in series for use; solvent, chloroform] to afford the title compound (124 mg, 55% yield) as a colorless viscous material.

Provenance & Evidence