Tributylstannane → HCID 178462418, compound

Participants

Reaction Steps

A chemical reaction was carried out according to a similar procedure to that described in Example 11-(4) using (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl]-1,3-dioxan-5-yl]thio]1-(2,4-difluorophenyl)-1-[(1H-1,2,4-triazol-1-yl)methyl]propyl 2-[(allyloxycarbonyl)oxymethyl]benzoate (1.52 g, 2.00 mmol), bis(triphenylphosphine)dichloropalladium (5 mg), and tributyltin hydride (620 mg, 2.13 mmol). The obtained crude product was subjected to chromatography on a silica gel (50 g) column (eluent; ethyl acetate:hexane=1:1˜1:0) to afford the title compound (1.096 g, 81% yield) as a colorless amorphous solid.

Provenance & Evidence