HCID 86760498, compound → HCID 87713388, compound

Participants

Reaction Steps

Allyl(S)-3-(allyloxycarbonylamino)-4-oxo-4-(2,2,2-trichloroethoxy)butyrate (350 mg, 9.02×10−4 mol) obtained from Example 20-(2) was dissolved in acetic acid (1.8 ml), then zinc powder (350 mg) was added thereto, and the resulting mixture was stirred at room temperature for 1 hour. The insoluble material was filtered off and washed with ethyl acetate. The filtrates were combined, and the solvent was distilled off under reduced pressure. The residue was dissolved in ethyl acetate, and the solution was washed successively with a 0.2N aqueous solution of hydrochloric acid and a saturated aqueous solution of sodium chloride. The resulting solution was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to afford the crude title compound (180 mg, 78% yield) as a pale yellow oil.

Provenance & Evidence