Sodium hydride → HCID 178460581, compound

Participants

Reaction Steps

According to a similar procedure to that described in Example 1-(12), 4-[(1E,3E)-4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]-1,3-butadienyl]-3-fluorobenzonitrile (976.6 mg, 1.80 mmol) described in Reference example 1, sodium hydride (55% dispersion in mineral oil; 94.2 mg, 1.96 mmol), and 2-[[bis(allyloxy)phosphoryl]oxymethyl]-3-methylbenzoyl chloride obtained above were reacted in tetrahydrofuran (10 ml), and the reaction mixture was worked up to afford, after extraction, the title compound as a crude oil. The crude oil was subjected to chromatography on a silica gel (100 g) column (eluent; ethyl acetate:hexane=3:2˜4:1) to afford the title compound (1.0641 g, 69% yield) as a pale yellow amorphous solid.

Provenance & Evidence