Sodium hydride → HCID 178460583, compound

Participants

Reaction Steps

According to a similar procedure to that described in Example 13-(2), 4-[(1E,3E)-4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]-1,3-butadienyl]-3-fluorobenzonitrile (690.5 mg, 1.27 mmol) described in Reference example 1, sodium hydride (55% dispersion in mineral oil; 66.5 mg, 1.52 mmol), and crude 4-[[bis(allyloxy)phosphoryl]oxymethyl]-3-furoyl chloride were reacted, and the reaction mixture was worked up to afford, after extraction, the title compound as a crude oil. The crude product was subjected to chromatography on a silica gel (30 g) column (eluent; ethyl acetate:hexane=2:1˜9:1) to afford the title compound (740.8 mg, 70% yield) as a colorless amorphous solid.

Provenance & Evidence