1-Methyl-4-(pent-4-ynyl)piperazine → 4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-5-(5-(4-methylpiperazin-1-yl)pent-1-ynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

HRID 176695Notes

Reaction equation

HRID 176695 reaction equation
[CH3:24][N:25]1[CH2:26][CH2:27][N:28]([CH2:31][CH2:32][CH2:33][C:34]#[CH:35])[CH2:29][CH2:30]1.[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([NH2:8])[n:7]1)[n:9]([CH2:13][c:14]1[n:15][cH:16][c:17]([CH3:23])[c:18]([O:21][CH3:22])[c:19]1[CH3:20])[cH:10][c:11]2[I:12]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([NH2:8])[n:7]1)[n:9]([CH2:13][c:14]1[n:15][cH:16][c:17]([CH3:23])[c:18]([O:21][CH3:22])[c:19]1[CH3:20])[cH:10][c:11]2[C:35]#[C:34][CH2:33][CH2:32][CH2:31][N:28]1[CH2:27][CH2:26][N:25]([CH3:24])[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 234461161-Methyl-4-(pent-4-ynyl)piperazineHCID 442289644-Chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Product 1

HCID 577138354-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-5-(5-(4-methylpiperazin-1-yl)pent-1-ynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Sources & evidence

ORD record
ord-ffd46842723e49e19eb63f921c8a848a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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