Phosphorus oxychloride → HCID 10214620, compound

Participants

Reaction Steps

To a solution of POCl3 (0.137 g, 0.892 mmole) in dry toluene (5 ml), N-(11-oxo-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-formamide (III; X=S, Y=Z=H. A=NH, R1=H) (0.06 g, 0.223 mmole) dissolved in toluene (10 ml) was added. The reaction mixture was heated under reflux for 2 hours. Then toluene was evaporated to dryness and water was added and it was extracted with ethyl acetate. The organic extract was washed with a saturated NaHCO3 solution and water and dried over anhydrous Na2SO4. The solvent was evaporated and, after purifying by chromatography on a column, an oily product was isolated.

Provenance & Evidence