HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1766989Generated: October 31, 2026
Sodium Hydroxide → 2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine
https://huagongshe.com/reaction/1766989
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one | HCID 567033 | — |
| Reactant | HCID 178426711 | HCID 178426711 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine | HCID 10686149 | — |
Reaction Steps
To a mixture of 2-methyl-5-nitrophenylguanidine nitrate (25 g, 96 mmol) and 3-dimethylamino-1-(3-pyridyl)-2-propen-1-one (17 g, 96 mmol) in isopropanol (200 ml) was added sodium hydroxide (4.5 g). The reaction was refluxed for 12 hours and cooled to 0° C. The precipitate was filtered and washed with isopropanol to give N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07232825B2 |
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| Source dataset | uspto-grants-2007_06 |
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| ORD ID | ord-f580364c29f64504950f13b31a84730c |
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| Source note | uspto-grants-2007_06 |
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