Formaldehyde → HCID 11785208, compound

HRID 1766994Notes

Reaction equation

HRID 1766994 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:16]=[CH:15][C:14]([N:17]([CH3:23])[CH:18]3[CH2:22][CH2:21][NH:20][CH2:19]3)=[CH:13][CH:12]=2)=[O:10])=[CH:4][C:3]=1[NH:24][C:25]1[N:30]=[C:29]([C:31]2[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=2)[CH:28]=[CH:27][N:26]=1.[CH2:37]=O>>[CH3:23][N:17]([CH:18]1[CH2:22][CH2:21][N:20]([CH3:37])[CH2:19]1)[C:14]1[CH:13]=[CH:12][C:11]([C:9]([NH:8][C:5]2[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([NH:24][C:25]3[N:30]=[C:29]([C:31]4[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=4)[CH:28]=[CH:27][N:26]=3)[CH:4]=2)=[O:10])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 11260144HCID 11260144, compound

Product 1

HCID 11785208HCID 11785208, compound

Procedure

The product from Example 7 was methylated via reductive amination with HCHO/NaBHCN (1.5 eq) to give the title compound. Mass: (M+1), 494.

Sources & evidence

ORD record
ord-66c7c87f3be34c22a1c62cfde4567ee9
Source dataset
uspto-grants-2007_06
Patent number
US07232825B2

Reaction notes

Loading…