HRID1766995

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID712

Formaldehyde

CH2O

结构：Cc1ccc(NC(=O)c2ccc(C(F)NC3CCN(C)C3)cc2)cc1Nc1nccc(-c2cccnc2)n1

HCID11237572

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)c2ccc(C(F)N(C)C3CCN(C)C3)cc2)cc1Nc1nccc(-c2cccnc2)n1

HCID11329935

未命名化合物

PROCEDURE

实验过程

The product from Example 11 was methylated via reductive amination with HCHO/NaBHCN afforded the title compound. Mass: (M+1), 526.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-519171dac6ed4d0b924d48d29ae70dbf
来源数据集: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07232825B2
来源说明: uspto-grants-2007_06

反应 SMILES

[F:1][CH:2]([NH:32][CH:33]1[CH2:37][CH2:36][N:35]([CH3:38])[CH2:34]1)[C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([NH:19][C:20]3[N:25]=[C:24]([C:26]4[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=4)[CH:23]=[CH:22][N:21]=3)[CH:13]=2)=[O:10])=[CH:5][CH:4]=1.[CH2:39]=O>>[F:1][CH:2]([N:32]([CH3:39])[CH:33]1[CH2:37][CH2:36][N:35]([CH3:38])[CH2:34]1)[C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([NH:19][C:20]3[N:25]=[C:24]([C:26]4[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=4)[CH:23]=[CH:22][N:21]=3)[CH:13]=2)=[O:10])=[CH:5][CH:4]=1