HRID1766996

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID177

Acetaldehyde

C2H4O

结构：Cc1ccc(NC(=O)c2ccc(C(F)(F)N3CCNCC3)cc2)cc1Nc1nccc(-c2cccnc2)n1

HCID11398195

未命名化合物

PRODUCTS

生成物

结构：CCN1CCN(C(F)(F)c2ccc(C(=O)Nc3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc2)CC1

HCID11398644

未命名化合物

PROCEDURE

实验过程

The product from Example 14 was ethylated via reductive amination with CH3CHO/NaBHCN afforded the title compound. Mass: (M+1), 544.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-031a68954fb541b4b42646ac76acb9d9
来源数据集: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07232825B2
来源说明: uspto-grants-2007_06

反应 SMILES

[F:1][C:2]([F:38])([N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)[C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([NH:19][C:20]3[N:25]=[C:24]([C:26]4[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=4)[CH:23]=[CH:22][N:21]=3)[CH:13]=2)=[O:10])=[CH:5][CH:4]=1.[CH3:39][CH:40]=O>>[CH2:39]([N:35]1[CH2:34][CH2:33][N:32]([C:2]([F:1])([F:38])[C:3]2[CH:4]=[CH:5][C:6]([C:9]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([NH:19][C:20]4[N:25]=[C:24]([C:26]5[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=5)[CH:23]=[CH:22][N:21]=4)[CH:13]=3)=[O:10])=[CH:7][CH:8]=2)[CH2:37][CH2:36]1)[CH3:40]