Methanol → HCID 10099592, compound

Participants

Reaction Steps

To a stirred solutionof 12 mg (0.023 mmol) of the 4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-(4-methyl-6-piperazin-1-yl-1H-benzimidazole-2-yl)-1H-quinoline-2-one in 0.5 mL of methanol was added ˜5 mg of glycaldehyde to which was added 0.3 mL of 1 N solution of sodiumcyanoborohydride in tetrahydrofuran, and the mixture was stirred for 30 minutes, and then it was subjected to preparative HPLC to afford the product. LRMS [M+H]+573; 1H NMR (400 MHz, CDCl3) δ 8.06 (d, 1H, J=7.96 Hz), 7.97 (s, 1H), 7.64 (dd, 1H, J=7.97, 8.4 Hz), 7.03-7.36 (m, 7H), 4.77 (m, 1H), 3.94 (t, 1H, J=5.1 Hz), 3.42-3.52(m, 8H), 3.36 (t, 1H, J=5.1 Hz), 3.31-3.47 (m, 4H), 2.63 (s, 3H).

Provenance & Evidence