HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 178499076, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 178418247 | HCID 178418247 | — |
| Reactant | HCID 178499078 | HCID 178499078 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178499076 | HCID 178499076 | — |
Reaction Steps
Crude material methyl 5-(benzoyloxy)-2-[4-(tert-butoxycarbonyl)-2-methylpiperazin-2-yl]-6-hydroxypyrimidine-4-carboxylate (C-44) obtained in step 1 was dissolved in MeOH, and NaCNBH3 (2.8 eq), AcONa (3.2 eq) and HCHO (37% in H2O, 4 eq) were added. The reaction mixture was stirred at room temperature. After 30′, the solvent was evaporated and the crude solid (C-45) obtained washed with Et2O.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07232819B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-991268eeeb3f4507b56d5dc011bdf30f |
| Source note | uspto-grants-2007_06 |