HCID 178481086, compound → HCID 178480807, compound

HRID 1767129Notes

Reaction equation

HRID 1767129 reaction equation
[F:1][C:2]1[CH:34]=[CH:33][C:5]([CH2:6][NH:7][C:8]([C:10]2[C:15]([OH:16])=[C:14]([OH:17])[N:13]=[C:12]([C:18]3([CH3:32])[N:23]([CH3:24])[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19]3)[N:11]=2)=[O:9])=[CH:4][CH:3]=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[CH3:24][N:23]1[CH2:22][CH2:21][NH:20][CH2:19][C:18]1([C:12]1[N:11]=[C:10]([C:8]([NH:7][CH2:6][C:5]2[CH:33]=[CH:34][C:2]([F:1])=[CH:3][CH:4]=2)=[O:9])[C:15]([OH:16])=[C:14]([OH:17])[N:13]=1)[CH3:32]

Participants

3

Reactant 1

HCID 178481086HCID 178481086, compound

Product 1

HCID 178480807HCID 178480807, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

Crude material tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimdin-2-yl)-3,4-dimethylpiperazine-1-carboxylate (C-46) was stirred in DCM/TFA (1:1) for 1 hour. Evaporation of the solvent afforded the crude title compound (C47).

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-47bb4a60fe914103825bed4cacee4801
Source dataset
uspto-grants-2007_06
Patent number
US07232819B2

Reaction notes

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