2-Amino-4-chlorobenzoic acid → 7-Chloro-3H-quinazolin-4-one

Participants

Reaction Steps

In a 2-mL volume stainless steel pressure-resistant vessel were placed 330 mg (1.9 mmol) of 4-chloroanthranilic acid, 403 mg (3.8 mmol) of methyl orthoformate, and 1.2 mL (8.4 mmol) of 15 wt. % ammonia methanol solution. The reaction was carried out at 120° C. for 2 hours. After the reaction was complete, the reaction mixture was cooled to room temperature and analyzed (according to absolute quantitative analysis) by high performance liquid chromatography. There was produced 343 mg (reaction yield: 99%) of 7-chloroquinazolin-4-one.

Provenance & Evidence