Methyl formate → 6-Iodoquinazolin-4-one

Participants

Reaction Steps

In a 2-mL volume stainless steel pressure-resistant vessel were placed 500 mg (1.9 mmol) of 5-iodoanthranilic acid, 342 mg (5.7 mmol) of methyl formate, and 1.2 mL (8.4 mmol) of 15 wt. % ammonia methanol solution. The reaction was carried out at 150° C. for 4 hours. After the reaction was complete, the reaction mixture was cooled to room temperature and analyzed (according to absolute quantitative analysis) by high performance liquid chromatography. There was produced 401 mg (reaction yield: 77%) of 6-iodoquinazolin-4-one.

Provenance & Evidence