2-Amino-4-chlorobenzoic acid → Ammonium 4-chloroanthranilate
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5](=[CH:9][CH:10]=1)[C:6]([OH:8])=[O:7].CO.[NH3:14]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5](=[CH:9][CH:10]=1)[C:6]([O-:8])=[O:7].[NH4+:14]Participants
3
Procedure
In a 50 mL volume glass vessel equipped with a stirrer and a thermometer were placed 5.0 g (29.1 mmol) of 4-chloroanthranilic acid and 20 mL (156 mmol) of 15 wt. % ammonia methanol solution. The reaction was carried out for 2 hours at room temperature. After the reaction was complete, the reaction mixture was concentrated under reduced pressure, to obtain 5.0 g (isolated yield: 95%) of ammonium 4-chloroanthranilate as white solid.
Workup
- customIn a 50 mL volume glass vessel equipped with a stirrer
- concentrationthe reaction mixture was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-848cbd6a052c4f4c8d5edfc351af3c39
- Source dataset
- uspto-grants-2007_06
- Patent number
- US07232903B2
Reaction notes
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