Ammonium 4-chloroanthranilate → 7-Chloro-3H-quinazolin-4-one

Participants

Reaction Steps

In a 2-mL volume stainless steel pressure-resistant vessel were placed 340 mg (1.8 mmol) of ammonium 4-chloroanthranilate (prepared in the same manner as in Reference Example 2), 400 mg (3.6 mmol) of methyl orthoformate, and 1.5 mL of methanol. The reaction was carried out at 120° C. for 2 hours. After the reaction was complete, the reaction mixture was cooled to room temperature and analyzed (according to absolute quantitative analysis) by high performance liquid chromatography. There was produced 176 mg (reaction yield: 54%) of 7-chloroquinazolin-4-one.

Provenance & Evidence